Systematic modifications were carried out at four positions around the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against in culture. molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate. in culture, is currently in clinical trials for Chagas disease, … Continue reading Systematic modifications were carried out at four positions around the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against in culture